Puffy nipples affect a lot of teens, both male and female. They come in many different shades and are sometimes hard to spot. Puffy nipples affect young girls, who can have them both as well as boys. They can either show that a girl is inexperienced in sex or not into getting pregnant, which could mean that she is having sex with a much older man. Puffy nipples can also show up during puberty, making the teen feel self-conscious about his body.